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Mitch Dowsett Selected Research

Aromatase Inhibitors

12/2023Effect of baseline oestradiol serum concentration on the efficacy of anastrozole for preventing breast cancer in postmenopausal women at high risk: a case-control study of the IBIS-II prevention trial.
12/2023Clinico-pathologic relationships with Ki67 and its change with short-term aromatase inhibitor treatment in primary ER + breast cancer: further results from the POETIC trial (CRUK/07/015).
1/2023Molecular profiling of aromatase inhibitor sensitive and resistant ER+HER2- postmenopausal breast cancers.
12/2022Relationship between ER expression by IHC or mRNA with Ki67 response to aromatase inhibition: a POETIC study.
9/2022HER2-enriched subtype and novel molecular subgroups drive aromatase inhibitor resistance and an increased risk of relapse in early ER+/HER2+ breast cancer.
1/2022Impact of Duration of Neoadjuvant Aromatase Inhibitors on Molecular Expression Profiles in Estrogen Receptor-positive Breast Cancers.
11/2020Use of anastrozole for breast cancer prevention (IBIS-II): long-term results of a randomised controlled trial.
11/2020Long-term outcome and prognostic value of Ki67 after perioperative endocrine therapy in postmenopausal women with hormone-sensitive early breast cancer (POETIC): an open-label, multicentre, parallel-group, randomised, phase 3 trial.
10/2020ESR1 Mutations and Overall Survival on Fulvestrant versus Exemestane in Advanced Hormone Receptor-Positive Breast Cancer: A Combined Analysis of the Phase III SoFEA and EFECT Trials.
12/2019Impact of aromatase inhibitor treatment on global gene expression and its association with antiproliferative response in ER+ breast cancer in postmenopausal patients.
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Mitch Dowsett Research Topics

Disease

272Breast Neoplasms (Breast Cancer)
12/2023 - 01/2002
135Neoplasms (Cancer)
12/2023 - 01/2002
4Disease Progression
10/2023 - 07/2006
4Neoplasm Metastasis (Metastasis)
10/2018 - 10/2007
4Pathologic Complete Response
06/2017 - 12/2010
4Prostatic Neoplasms (Prostate Cancer)
02/2012 - 11/2005
4Sexually Transmitted Diseases (Sexually Transmitted Disease)
02/2008 - 01/2003
4Hypersensitivity (Allergy)
07/2005 - 08/2002
3Noninfiltrating Intraductal Carcinoma (DCIS)
12/2023 - 05/2013
3Triple Negative Breast Neoplasms
10/2022 - 09/2008
3Hypertension (High Blood Pressure)
04/2017 - 10/2008
3Arthralgia (Joint Pain)
04/2017 - 09/2013
3Residual Neoplasm
01/2016 - 07/2012
3Cardiovascular Diseases (Cardiovascular Disease)
07/2014 - 12/2007
3Overweight
04/2014 - 07/2010
3Bone Resorption
02/2004 - 07/2002
2Melanoma (Melanoma, Malignant)
11/2020 - 12/2010
2Ovarian Neoplasms (Ovarian Cancer)
01/2020 - 12/2010
2Endometrial Neoplasms (Endometrial Cancer)
02/2016 - 12/2010
2Carcinogenesis
06/2015 - 01/2005
2Colorectal Neoplasms (Colorectal Cancer)
03/2015 - 09/2010
2Amenorrhea
08/2013 - 06/2006
2Weight Gain
07/2012 - 06/2007
2Hypokalemia
02/2012 - 10/2008

Drug/Important Bio-Agent (IBA)

88Estrogen ReceptorsIBA
10/2023 - 02/2002
62Aromatase InhibitorsIBA
12/2023 - 07/2002
62Hormones (Hormone)IBA
12/2023 - 01/2003
60Estrogens (Estrogen)FDA Link
12/2019 - 01/2002
57TamoxifenFDA LinkGeneric
01/2022 - 01/2002
46Anastrozole (Arimidex)FDA LinkGeneric
12/2023 - 02/2002
31Biomarkers (Surrogate Marker)IBA
01/2022 - 08/2003
25Estradiol (Delestrogen)FDA LinkGeneric
12/2023 - 01/2005
24Progesterone Receptors (Progesterone Receptor)IBA
12/2019 - 01/2003
20Trastuzumab (Herceptin)FDA Link
02/2019 - 01/2002
19Letrozole (Femara)FDA LinkGeneric
12/2023 - 02/2002
18Proteins (Proteins, Gene)FDA Link
10/2023 - 08/2002
16Aromatase (CYP19)IBA
12/2019 - 01/2002
14Gonadal Steroid Hormones (Sex Hormones)IBA
05/2014 - 06/2004
13Fulvestrant (Faslodex)FDA Link
10/2023 - 08/2002
11human ERBB2 proteinIBA
01/2023 - 08/2005
11AndrogensIBA
08/2013 - 07/2002
9Sex Hormone-Binding GlobulinIBA
12/2023 - 11/2005
9Phenobarbital (Luminal)FDA Link
01/2022 - 08/2007
9Estrogen Receptor alphaIBA
10/2019 - 08/2002
9ParaffinIBA
01/2016 - 01/2004
8Testosterone (Sustanon)FDA Link
12/2023 - 11/2005
8Formaldehyde (Formol)FDA Link
01/2016 - 03/2008
8EstroneFDA Link
05/2014 - 10/2006
8SteroidsIBA
08/2013 - 07/2005
7Messenger RNA (mRNA)IBA
12/2022 - 03/2002
7ErbB Receptors (EGF Receptor)IBA
09/2022 - 01/2005
7Epidermal Growth Factor (EGF)IBA
01/2022 - 04/2003
7RNA (Ribonucleic Acid)IBA
02/2021 - 03/2010
7ProgesteroneFDA LinkGeneric
01/2019 - 10/2006
7Monoclonal AntibodiesIBA
01/2017 - 01/2005
6Circulating Tumor DNAIBA
01/2020 - 08/2015
5palbociclibIBA
10/2023 - 01/2016
5Mechanistic Target of Rapamycin Complex 1IBA
01/2020 - 11/2010
5DNA (Deoxyribonucleic Acid)IBA
01/2018 - 01/2007
5Raloxifene Hydrochloride (Evista)FDA Link
05/2013 - 10/2003
5Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
11/2010 - 01/2005
5Tyrosine Kinase InhibitorsIBA
06/2009 - 01/2003
42- benzylidene- 3- (cyclohexylamino)- 2,3- dihydro- 1H- inden- 1- oneIBA
10/2021 - 10/2013
4LigandsIBA
10/2019 - 10/2008
4Cyclin D1IBA
01/2018 - 10/2003
4Phosphotransferases (Kinase)IBA
01/2016 - 11/2010
4Selective Estrogen Receptor Modulators (SERM)IBA
05/2013 - 08/2003
3ChromatinIBA
10/2023 - 09/2011
3exemestane (Aromasin)FDA Link
10/2020 - 09/2013
3abirateroneIBA
01/2020 - 02/2012
3Androgen Receptors (Androgen Receptor)IBA
01/2018 - 10/2008
3Lapatinib (GW572016)FDA Link
07/2015 - 08/2007
3GlucuronidesIBA
05/2014 - 11/2005
3estrone sulfate (Evex)FDA Link
08/2012 - 10/2006
3Abiraterone AcetateIBA
02/2012 - 10/2008
3Estrogen Receptor Modulators (Antiestrogen)IBA
09/2011 - 10/2003
3EnzymesIBA
08/2011 - 07/2002
3Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA
08/2009 - 06/2004
3AnthracyclinesIBA
09/2008 - 12/2007
3Androstenedione (4 Androstene 3,17 dione)IBA
06/2008 - 07/2006
3Gefitinib (Iressa)FDA Link
09/2007 - 01/2005
3IsoflavonesIBA
09/2006 - 01/2004
3Phytoestrogens (Phytoestrogen)IBA
11/2005 - 05/2004
3Complementary DNA (cDNA)IBA
01/2004 - 01/2002
2vistusertibIBA
01/2020 - 12/2019
2Glycoproteins (Glycoprotein)IBA
01/2018 - 04/2003
2Docetaxel (Taxotere)FDA Link
01/2017 - 10/2007
2CholesterolIBA
01/2016 - 12/2007
2Cytochrome P-450 CYP3AIBA
05/2014 - 05/2012
2Cytochrome P-450 CYP2D6 (CYP2D6)IBA
07/2013 - 03/2012
2TOR Serine-Threonine KinasesIBA
10/2012 - 11/2010
2Dexamethasone (Maxidex)FDA LinkGeneric
02/2012 - 08/2009

Therapy/Procedure

110Therapeutics
12/2023 - 01/2002
23Drug Therapy (Chemotherapy)
01/2019 - 01/2002
20Neoadjuvant Therapy
01/2023 - 01/2005
15Adjuvant Chemotherapy
01/2021 - 10/2005
6Chemoprevention
04/2008 - 01/2006
4Aftercare (After-Treatment)
11/2020 - 07/2007
3Castration
02/2012 - 10/2008
2Precision Medicine
01/2018 - 12/2008